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游文萱
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游文萱
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 ===== Journal Papers / 期刊論文 =====
-  - Huang, C.-T., Hsieh, C.-H., Chung, Y.-H., Oyang, Y.-J., Huang, H.-C.*, __**Juan, H.-F.**__* (2019) "Perturbational gene-expression signatures for combinatorial drug discovery" //iScience// (**Cell Press**, doi: 10.1016/j.isci.2019.04.039).
+  - Cheung, H. Y. C., Hsu, C.-L., Tsuei, C.-Y., Kuo, T.-T., Huang, C.-T., Hsu, W.-M., Chung, Y.-H., Wu, H.-Y., Hsu, C.-C., Huang, H.-C.*, __**Juan, H.-F.**__* (2019) "Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy" //Cell Death and Disease// (Accepted).
-  - Huang, C.-T., Hsieh, C.-H., Lee, W.-C., Liu, Y.-L., Yang, T.-S., Hsu, W.-M., Oyang, Y.-J., Huang, H.-C.*, __**Juan, H.-F.**__* "Therapeutic targeting of non-oncogene dependencies in high-risk neuroblastoma" //Clinical Cancer Research// (Accepted).
+  - Hsieh, C.-H., Cheung, C. H. Y., Liu, Y.-L., Hou, C.-L., Hsu, C.-L., Huang, C.-T., Yang, T.-S., Chen, S.-F., Chen, C.-N., Hsu, W.-M.*, Huang, H.-C.*, __**Juan, H.-F.**__* (2019) "Quantitative proteomics of Th-MYCN transgenic mice reveals aurora kinase inhibitor altered metabolic pathways and enhanced ACADM to suppress neuroblastoma progression" //Journal of Proteome Research// (Accepted).
+  - Chang, H.-C., Huang, H.-C., __**Juan, H.-F.**__*, Hsu, C.-L* (2019) "Investigating the role of super-enhancer RNAs underlying embryonic stem cell differentiation" //BMC Genomics// (Accepted).
+  - Wu, P.-Y., Yu, I-S., Lin, Y.-C., Chang, Y.-T., Chen, C.-C., Lin, K.-H., Tseng, T.-H., Kargren, M., Tai, Y.-L., Shen, T.-L., Liu, Y.-L., Wang, B.-J., Chang, C.-H., Chen, W.-M., __Juan, H.-F.__, Huang, S.-F., Chan, Y.-Y., Liao, Y.-F., Hsu, W.-M., Lee, H. (2019) "Activation of aryl hydrocarbon receptor by kynurenine impairs progression and metastasis of neuroblastoma" //Cancer Research// (in press).
+  - Huang, C.-T., Hsieh, C.-H., Lee, W.-C., Liu, Y.-L., Yang, T.-S., Hsu, W.-M., Oyang, Y.-J., Huang, H.-C.*, __**Juan, H.-F.**__* (2019) "Therapeutic targeting of non-oncogene dependencies in high-risk neuroblastoma" //Clinical Cancer Research// 25(13):4063-4078.
+  - Huang, C.-T., Hsieh, C.-H., Chung, Y.-H., Oyang, Y.-J., Huang, H.-C.*, __**Juan, H.-F.**__* (2019) "Perturbational gene-expression signatures for combinatorial drug discovery" //iScience// 15:291-306 (**Cell Press**).
   - Yang, T.-W., Sahu, D., Chang, Y.-W., Hsu, C.-L., Hsieh, C.-H., Huang, H.-C.*, __**Juan, H.-F.**__* (2019) “RNA-binding proteomics reveals MATR3 interacting with lncRNA SNHG1 to enhance neuroblastoma progression” //Journal of Proteome Research// 18: 406–416.
   - Chang, J.-Y., Yu, W.-H., __**Juan, H.-F.**__*, Huang, H.-C.* (2018) "Dynamics of alternative polyadenylation in human preimplantation embryos" //Biochemical and Biophysical Research// Sep 11. pii: S0006-291X(18)31946-6.
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   - __**Juan, H.-F.**__, Hung, C.-C., Wang, K.-T., Chiou, S.-H.* (1999) “Comparison of three classes of snake neurotoxins by homology modeling and computer simulation graphics.” Biochem Biophys Res Commun. 257: 500-510.
 ===== Conference Proceedings / 研討會論文 =====
+  - Kao, Y.-C., Chang, N.-W., Chang, Y.-W., Lai, C. P., Huang, H.-C. and __**Juan, H.-F.**__* "Ectopic ATP synthase induces extracellular vesicle release for cell-to-cell communications" The 8th Congress of the International Society for Extracellular Vesicles (ISEV2019), Kyoto, Japan, April 24-28, 2019.
+  - Wang, C.-C., Chang, Y.-W., Wu, C.-H., Cheung, C. H. Y., Lee, J.-L., Huang, H.-C.* and __**Juan, H.-F.**__* "Mesenchymal stem cells-derived microenvironment promote lung cancer cell progression via c-Fos S374 phosphorylation in MAPK signaling pathway" //34th Joint Annual Conference of Biomedical Sciences//, Taipei, Taiwan, March 23-24, 2019. (**Best Poster Award**)
+  - Tsai, H.-H., Wang, W.-H., Hou, J.-T., Hsieh, C.-H., Chang, Y.-W., Huang, H.-C.* and __**Juan, H.-F.**__* "Investigation of molecular mechanism in mitochondria fission leading ATP synthase toward cell surface" //34th Joint Annual Conference of Biomedical Sciences//, Taipei, Taiwan, March 23-24, 2019. (**Best Poster Award**)
+  - Yang, F.-M., Kuo, I.-Y., __**Juan, H.-F.**__, Wang, Y.-C.*. 2019 Rab37-mediated IL-6 secretion in the polarization of macrophages. The 34th joint annual conference of biomedical sciences. (**Best Poster Award**).
+  - Lee, W.-H., Chen, K.-P., Huang, H.-C.* and __**Juan, H.-F.**__* "Exploring cancer-associated microbiome characteristics using large-scale patient small RNA sequencing data" //34th Joint Annual Conference of Biomedical Sciences//, Taipei, Taiwan, March 23-24, 2019.
+  - Chang, N.-W., Kao, Y.-C., Chang, Y.-W., Lai, C. P., Huang, H.-C.* and __**Juan, H.-F.**__* "The function of ectopic ATP synthase in extracellular vesicles under serum deprivation" //34th Joint Annual Conference of Biomedical Sciences//, Taipei, Taiwan, March 23-24, 2019.
+  - Liaw, Y-g., Chang, Y.-W., Hung, Y.-H., Huang, H.-C.* and __**Juan, H.-F.**__* "Live-cell imaging of ectopic ATP synthase trafficking" //34th Joint Annual Conference of Biomedical Sciences//, Taipei, Taiwan, March 23-24, 2019.
   - Cheung, H. Y. C., Hsu, C.-L., Tsuei, C.-Y., Kuo, T.-T., Huang, C.-T., Wu, H.-Y., Hsu, C.-C. Chung, Y.-H., Huang, H.-C.* and __**Juan, H.-F.**__* "MYCN-mediated purine biosynthesis enhances cancer metabolism via MTHFD2 and PAICS in neuroblastoma" //2017 Taiwan Proteomics Society (TPS) Annual Meeting//, Taichung, Taiwan, Nov. 17, 2018. (**1st Prize Poster Award**)
   - Wang, W.-H., Hsu, C.-L., Huang, H.-C.* and __**Juan, H.-F.**__* "Phosphoproteomics reveals cyclic stretch induces microtubule rearrangement, changes cell alignment and disrupts mitochondrial dynamics in lung cells" //2018 The Taiwan Society for Biochemistry and Molecular Autumn Camp//, Chitou, Taiwan, Nov. 9-11, 2018.
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   - Chiou, S.-H., __**Juan, H.-F.**__ and Huang, H.-C. (1995) “Octopus S-crystallins with endogenous glutathione S-transferase activity: computer graphic modelling and sequence comparison with authentic enzymes.” (Abstract#619-M) 9th Symposium of the Protein Society, Boston, MA, U. S. A., July 8-12.
 ===== Books (Chapters) / 專書（章節） =====
+  - __**Juan, H.-F.**__ (2019) "Proteomic techniques and their applications" in Biomolecular and Bioanalytical Techniques: Theory, Methodology and Applications, Edited by Vasudevan Ramesh (John Wiley & Sons, Inc., UK), pp.81-99.
+  - Siddiqui, H., Sami, F., __**Juan, H.-F.**__* and Hayat, S.* (2019) "Brassinosteroid Regulated Physiological Process: An Omics Perspective" Brassinosteroids: Plant Growth and Development, ed. By Shamsul Hayat, Dr. Mohammad Yusuf, Dr. Renu Bhardwaj & Dr. Andrzej Bajguz (Springer Nature, Singapore), pp. 297-322.
   - __**Juan, H.-F.**__ and Huang, H.-C. (2018) A Practical Guide to Cancer Systems Biology (World Scientific Publishing, Singapore)
+  - __**Juan, H.-F.**__ (2017) "Data Sources for herbal and traditional medicines" in Computational Systems Pharmacology and Toxicology, Edited by Dale Johnson and Rudy J Richardson (The Royal Society of Chemistry, Cambridge, UK), pp. 243-260.
   - __**Juan, H.-F.**__ and Huang, H.-C. (2012) Systems Biology: Applications in cancer-related research (World Scientific Publishing, Singapore).
   - __**Juan, H.-F.**__ (2011) "Transcriptomics and proteomics study in regulation of brassinosteroids" in Brassinosteroids: A Class of Plant Hormone, ed. Shamsul Hayat and Aqil Ahmad (Springer, Netherlands), pp. 393-402.

Juan's Systems Biology Laboratory

From proteins to proteomics and beyond.... Aimed for drug discovery and bioenergy development; Systems & synthetic biology research

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